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1

Stretch-Shortening Drills for the Upper Extremities: Theory and Clinical Application

Wilk, Kevin E., Voight, Michael L., Keirns, Michael A., Gambetta, Vern, Andrews, James R., Dillman, Charles J.

Journal:

Journal of Orthopaedic and Sports Physical Therapy

Year:

1993

Language:

english

File:

PDF, 3.80 MB

english, 1993

2

Pharmacokinetics, Pharmacodynamics, and Safety of ASP015K (Peficitinib), a New Janus Kinase Inhibitor, in Healthy Subjects

Cao, Ying Jun, Sawamoto, Taiji, Valluri, Udaya, Cho, Kathy, Lewand, Michaelene, Swan, Suzanne, Lasseter, Kenneth, Matson, Mark, Holman, John, Keirns, James, Zhu, Tong

Journal:

Clinical Pharmacology in Drug Development

Year:

2016

Language:

english

File:

PDF, 2.03 MB

english, 2016

3

Pharmacokinetics of Novel Atrial-Selective Antiarrhythmic Agent Vernakalant Hydrochloride Injection (RSD1235): Influence of CYP2D6 Expression and Other Factors

Mao, Zhongping L., Wheeler, Jeffery J., Clohs, Lilian, Beatch, Gregory N., Keirns, James

Journal:

Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 231 KB

english, 2009

4

Assessment of Tacrolimus Absorption From the Human Intestinal Tract: Open-Label, Randomized, 4-Way Crossover Study

Tsunashima, Daisuke, Kawamura, Akio, Murakami, Manabu, Sawamoto, Taiji, Undre, Nas, Brown, Malcolm, Groenewoud, Albert, Keirns, James J., Holman, John, Connor, Alyson, Wylde, Hannah, Wilding, Ian, Oga

Journal:

Clinical Therapeutics

Year:

2014

Language:

english

File:

PDF, 423 KB

english, 2014

5

The Effect of Moderate Hepatic Impairment on the Pharmacokinetics of Ipragliflozin, a Novel Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor

Zhang, Wenhui, Krauwinkel, Walter J. J., Keirns, James, Townsend, Robert W., Lasseter, Kenneth C., Plumb, Lisa, Kadokura, Takeshi, Ushigome, Fumihiko, Smulders, Ronald

Journal:

Clinical Drug Investigation

Year:

2013

Language:

english

File:

PDF, 328 KB

english, 2013

6

Oral pharmacokinetics of pirenzepine in man following single and multiple doses

Matzek, Kandace M., MacGregor, Thomas R., Keirns, James J., Vinocur, Myron, Hurwitz, Aryeh

Journal:

International Journal of Pharmaceutics

Year:

1986

Language:

english

File:

PDF, 755 KB

english, 1986

7

Pharmacokinetics of Micafungin in Healthy Volunteers, Volunteers With Moderate Liver Disease, and Volunteers With Renal Dysfunction

Hebert, Mary F., Smith, Helen E., Marbury, Thomas C., Swan, Suzanne K., Smith, William B., Townsend, Robert W., Buell, Donald, Keirns, James, Bekersky, Ihor

Journal:

Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

8

Are QTc interval changes after meal intake a reasonable method to prove assay sensitivity in thorough QT studies?

Hnatkova, Katerina, Kowalski, Donna, Keirns, James J., van Gelderen, E. Marcel, Malik, Marek

Journal:

Journal of Electrocardiology

Year:

2015

Language:

english

File:

PDF, 96 KB

english, 2015

9

Advances in Cyclic Nucleotide Research. Vol. 3by Paul Greengard; G. Alan Robison

Review by: James J. Keirns

Journal:

American Scientist

Year:

1974

Language:

english

File:

PDF, 367 KB

english, 1974

10

William J. Zwiebel

Matzek, Kandace M., MacGregor, Thomas R., Keirns, James J., Vinocur, Myron, Hurwitz, Aryeh

Journal:

Current Problems in Diagnostic Radiology

Year:

1986

Language:

english

File:

PDF, 29.41 MB

english, 1986

11

Effect of Renal or Hepatic Impairment on the Pharmacokinetics of Mirabegron

James Dickinson, Michaelene Lewand, Taiji Sawamoto, Walter Krauwinkel, Marloes Schaddelee, James Keirns, Virginie Kerbusch, Selina Moy, John Meijer, Donna Kowalski, Richard Morton, Kenneth Lasseter, D

Journal:

Clinical Drug Investigation

Year:

2013

Language:

english

File:

PDF, 395 KB

english, 2013

12

Ipragliflozin Does Not Prolong QTc Interval in Healthy Male and Female Subjects: A Phase I Study

Zhang, Wenhui, Smulders, Ronald, Abeyratne, Anura, Dietz, Albert, Krauwinkel, Walter, Kadokura, Takeshi, Keirns, James

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 283 KB

english, 2013

13

Effect of food and antacids on the oral absorption of pirenzepine in man

Matzek, Kandace M., MacGregor, Thomas R., Keirns, James J., Vinocur, Myron

Journal:

International Journal of Pharmaceutics

Year:

1986

Language:

english

File:

PDF, 558 KB

english, 1986

14

Cyclic adenosine monophosphate and clinical medicine Part II: Carbohydrate and lipid metabolism

KEIRNS, JAMES J., FREEMAN, J, BITENSKY, MARK W.

Journal:

The American Journal of the Medical Sciences

Year:

1974

File:

PDF, 1.54 MB

1974

15

Evaluation of the Effect of 5 QT‐Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ‐CSRC Study

Darpo, Borje, Benson, Charles, Brown, Randy, Dota, Corina, Ferber, Georg, Ferry, Jim, Jarugula, Venkat, Keirns, James, Ortemann‐Renon, Catherine, Pham, Thuan, Riley, Steve, Sarapa, Nenad, Ticktin, Mar

Journal:

Journal of Clinical Pharmacology

Year:

2019

Language:

english

File:

PDF, 352 KB

english, 2019

16

Pharmacokinetics of conivaptan hydrochloride, a vasopressin V1A/V2-receptor antagonist, in patients with euvolemic or hypervolemic hyponatremia and with or without congestive heart failure from a prospective, 4-day open-label study

Zhongping Lily Mao, Dennis Stalker, James Keirns

Journal:

Clinical Therapeutics

Year:

2009

Language:

english

File:

PDF, 866 KB

english, 2009

17

THE AMPHIBIAN MELANOCYTE: MICROTUBULES, CYCLIC AMP, AND ORGANELLE TRANSLOCATION

Mark W. Bitensky, Candace N. Keirns, James J. Keirns

Journal:

Annals of the New York Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 409 KB

english, 1975

18

Statistical analysis of Amenamevir (ASP2151) between pharmacokinetics and clinical efficacies with non-linear effect model for the treatment of genital herpes

Takada, Akitsugu, Katashima, Masataka, Kaibara, Atsunori, Sawamoto, Taiji, Zhang, Wenhui, Keirns, James

Journal:

Clinical Pharmacology in Drug Development

Year:

2014

Language:

english

File:

PDF, 350 KB

english, 2014

19

The Pharmacokinetics and Safety of Micafungin, a Novel Echinocandin, in Premature Infants

Heresi, Gloria P., Gerstmann, Dale R., Reed, Michael D., van den Anker, John N., Blumer, Jeffrey L., Kovanda, Laura, Keirns, James J., Buell, Donald N., Kearns, Gregory L.

Journal:

Pediatric Infectious Disease Journal

Year:

2006

Language:

english

File:

PDF, 312 KB

english, 2006

20

QTc changes after meal intake: Sex differences and correlates

Hnatkova, Katerina, Kowalski, Donna, Keirns, James J., van Gelderen, E. Marcel, Malik, Marek

Journal:

Journal of Electrocardiology

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

21

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients With Atrial Fibrillation or Atrial Flutter

Mao, Zhongping Lily, Townsend, Robert W., Gao, Yuying, Wheeler, Jeffrey J., Kastrissios, Helen, Keirns, James

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 398 KB

english, 2012

22

Link between rhodopsin and disk membrane cyclic nucleotide phosphodiesterase. Action spectrum and sensitivity to illumination

Keirns, James J., Miki, Naomasa, Bitensky, Mark W., Keirns, Mary

Journal:

Year:

1975

Language:

english

File:

PDF, 883 KB

english, 1975

23

Concomitant Tacrolimus and Micafungin Pharmacokinetics in Healthy Volunteers

Hebert, Mary F., Blough, David K., Townsend, Robert W., Allison, Mark, Buell, Donald, Keirns, James, Bekersky, Ihor

Journal:

Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

24

Can Bias Evaluation Provide Protection Against False-Negative Results in QT Studies Without a Positive Control Using Exposure-Response Analysis?

Ferber, Georg, Zhou, Meijian, Dota, Corina, Garnett, Christine, Keirns, James, Malik, Marek, Stockbridge, Norman, Darpo, Borje

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

25

The Effect of Verapamil, a P-Glycoprotein Inhibitor, on the Pharmacokinetics of Peficitinib, an Orally Administered, Once-Daily JAK Inhibitor

Zhu, Tong, Howieson, Corrie, Wojtkowski, Tomasz, Garg, Jay P., Han, David, Fisniku, Ogert, Keirns, James

Journal:

Clinical Pharmacology in Drug Development

Year:

2017

Language:

english

File:

PDF, 554 KB

english, 2017

26

Population pharmacokinetic–pharmacodynamic analysis of vernakalant hydrochloride injection (RSD1235) in atrial fibrillation or atrial flutter

Zhongping Mao, Jeff J. Wheeler, Robert Townsend, Yuying Gao, Smita Kshirsagar, James J. Keirns

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2011

Language:

english

File:

PDF, 1.92 MB

english, 2011

27

Adenosine 3′,5′ cyclic monophosphate in Euglena gracilis

James J. Keirns, Ben Carritt, Jenny Freeman, Jerome M. Eisenstadt, Mark W. Bitensky

Journal:

Year:

1973

Language:

english

File:

PDF, 561 KB

english, 1973

28

Stretch-Shortening Drills for the Upper Extremities: Theory and Clinical Application

Wilk, Kevin E., Voight, Michael L., Keirns, Michael A., Gambetta, Vern, Andrews, James R., Dillman, Charles J.

Journal:

Journal of Orthopaedic and Sports Physical Therapy

Year:

1993

File:

PDF, 3.80 MB

1993

29

An abrupt temperature-dependent change in the energy of activation of hormone-stimulated hepatic adenylyl cyclase

James J. Keirns, Peter W. Kreiner, Mark W. Bitensky

Journal:

Journal of Cellular Biochemistry

Year:

1973

Language:

english

File:

PDF, 606 KB

english, 1973

30

Reproducibility of QTc interval changes after meal intake

Hnatkova, Katerina, Kowalski, Donna, Keirns, James J., van Gelderen, E. Marcel, Malik, Marek

Journal:

Journal of Electrocardiology

Year:

2015

Language:

english

File:

PDF, 2.69 MB

english, 2015

31

Importance of subject-specific QT/RR curvatures in the design of individual heart rate corrections of the QT interval

Malik, Marek, Hnatkova, Katerina, Kowalski, Donna, Keirns, James J., van Gelderen, E. Marcel

Journal:

Journal of Electrocardiology

Year:

2012

Language:

english

File:

PDF, 5.51 MB

english, 2012

32

The IQ-CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”

Darpo, Borje, Sarapa, Nenad, Garnett, Christine, Benson, Charles, Dota, Corina, Ferber, Georg, Jarugula, Venkateswar, Johannesen, Lars, Keirns, James, Krudys, Kevin, Ortemann-Renon, Catherine, Riley,

Journal:

Annals of Noninvasive Electrocardiology

Year:

2014

Language:

english

File:

PDF, 311 KB

english, 2014

33

Cyclic adenosine monophosphate and clinical medicine

BITENSKY, MARK W., KEIRNS, JAMES J., FREEMAN, J

Journal:

The American Journal of the Medical Sciences

Year:

1973

File:

PDF, 1.41 MB

1973

34

Have individual QT/RR curvatures value in QT correction?

Malik, Marek, Hnatkova, Katerina, Kowalski, Donna, Keirns, James J., van Gelderen, E. Marcel

Journal:

Journal of Electrocardiology

Year:

2014

Language:

english

File:

PDF, 644 KB

english, 2014

35

Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14

Darpo, Borje, Garnett, Christine, Keirns, James, Stockbridge, Norman

Journal:

Year:

2015

Language:

english

File:

PDF, 856 KB

english, 2015

36

Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies

Kusawake, Tomohiro, Keirns, James J., Kowalski, Donna, den Adel, Martin, Groenendaal-van de Meent, Dorien, Takada, Akitsugu, Ohtsu, Yoshiaki, Katashima, Masataka

Journal:

Advances in Therapy

Year:

2017

Language:

english

File:

PDF, 582 KB

english, 2017

37

Light regulation of adenosine 3′, 5′ cyclic monophosphate levels in vertebrate photoreceptors

Naomasa Miki, James J. Keirns, Frederick R. Marcus, Mark W. Bitensky

Journal:

Experimental Eye Research

Year:

1974

Language:

english

File:

PDF, 1.18 MB

english, 1974

38

THE HYDROSTATIC BED.

Tsunashima, Daisuke, Kawamura, Akio, Murakami, Manabu, Sawamoto, Taiji, Undre, Nas, Brown, Malcolm, Groenewoud, Albert, Keirns, James J., Holman, John, Connor, Alyson, Wylde, Hannah, Wilding, Ian, Oga

Journal:

Year:

1844

Language:

english

File:

PDF, 354 KB

english, 1844

39

The Influence of Hepatic and Renal Impairment on the Pharmacokinetics of a Treatment for Herpes Zoster, Amenamevir (ASP2151): Phase 1, Open-Label, Single-Dose, Parallel-Group Studies

Kusawake, Tomohiro, Kowalski, Donna, Takada, Akitsugu, Kato, Kota, Katashima, Masataka, Keirns, James J., Lewand, Michaelene, Lasseter, Kenneth C., Marbury, Thomas C., Preston, Richard A.

Journal:

Advances in Therapy

Year:

2017

Language:

english

File:

PDF, 799 KB

english, 2017

40

Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor

David J. Hauss, Steven E. Fogal, James V. Ficorilli, Caswall A. Price, Tapon Roy, Andrew A. Jayaraj, James J. Keirns

Journal:

Journal of Pharmaceutical Sciences

Year:

1998

Language:

english

File:

PDF, 76 KB

english, 1998

41

Chlorthalidone pharmacodynamics in beagle dogs

Thomas R. Macgregor, James J. Keirns, Peter R. Farina, Kandace M. Matzek, Stephen T. Horhota, Henry J. Esber

Journal:

Journal of Pharmaceutical Sciences

Year:

1985

Language:

english

File:

PDF, 547 KB

english, 1985

42

Isolation of cyclic AMP and cyclic GMP by thin-layer chromatography. Application to assay of adenylate cyclase, guanylate cyclase, and cyclic nucleotide phosphodiesterase

James J. Keirns, Marcia A. Wheeler, Mark W. Bitensky

Journal:

Analytical Biochemistry

Year:

1974

Language:

english

File:

PDF, 750 KB

english, 1974

43

Part II || Regulation of Cyclic Nucleotide Concentrations in Photoreceptors: An ATP-Dependent Stimulation of Cyclic Nucleotide Phosphodiesterase by Light

Naomasa Miki, James J. Keirns, Frederick R. Marcus, Jenny Freeman and Mark W. Bitensky

Journal:

Proceedings of the National Academy of Sciences

Year:

1973

Language:

english

File:

PDF, 917 KB

english, 1973

44

The Pharmacokinetics and Pharmacodynamics of Micafungin in Experimental Hematogenous Candida Meningoencephalitis: Implications for Echinocandin Therapy in Neonates

Hope, William W., Mickiene, Diana, Petraitis, Vidmantas, Petraitiene, Ruta, Kelaher, Amy M., Hughes, Joanna E., Cotton, Margaret P., Bacher, John, Keirns, James J., Buell, Donald, Heresi, Gloria, Benj

Journal:

The Journal of Infectious Diseases

Year:

2008

Language:

english

File:

PDF, 5.29 MB

english, 2008

45

Pharmacokinetics of transdermally delivered clonidine

MacGregor, Thomas R, Matzek, Kandace M, Keirns, James J, van Wayjen, Rudolf G A, van den Ende, Abraham, van Tol, Rudolf G L

Journal:

Clinical Pharmacology & Therapeutics

Year:

1985

Language:

english

File:

PDF, 472 KB

english, 1985

46

Effects of Food Intake on the Pharmacokinetic Properties of Mirabegron Oral Controlled-Absorption System: A Single-Dose, Randomized, Crossover Study in Healthy Adults

Lee, Jennifer, Zhang, Wenhui, Moy, Selina, Kowalski, Donna, Kerbusch, Virginie, van Gelderen, Marcel, Sawamoto, Taiji, Grunenberg, Nicole, Keirns, James

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 367 KB

english, 2013

47

Clinical Pharmacokinetics and Pharmacodynamics of the Novel SGLT2 Inhibitor Ipragliflozin

Kadokura, Takeshi, Zhang, Wenhui, Krauwinkel, Walter, Leeflang, Stefanie, Keirns, James, Taniuchi, Yuta, Nakajo, Ikumi, Smulders, Ronald

Journal:

Clinical Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 476 KB

english, 2014

48

ICH E14-Compatible Holter Bin Method and its Equivalence to Individual Heart Rate Correction in the Assessment of Drug-Induced QT Changes

MALIK, MAREK, HNATKOVA, KATERINA, KOWALSKI, DONNA, KEIRNS, JAMES J., GELDEREN, E. MARCEL VAN

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

49

Relative bioavailability of chlorthalidone in humans after single oral doses

Peter R. Farina, Thomas R. Macgregor, Stephen T. Horhota, James J. Keirns

Journal:

Journal of Pharmaceutical Sciences

Year:

1985

Language:

english

File:

PDF, 437 KB

english, 1985

50

Biologic Activity of Purified Cotton Bract Extracts in Man and Guinea Pig

Marion G. Buck, E. Neil Schachter, Robert B. Fick, William W. Merrill, J. Allen D. Cooper, Jr., James J. Keirns, James Oliver and James H. Wall

Journal:

Environmental Health Perspectives

Year:

1986

Language:

english

File:

PDF, 1.61 MB

english, 1986

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